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ⓘ Tadamitsu Kishimoto




Tadamitsu Kishimoto
                                     

ⓘ Tadamitsu Kishimoto

Tadamitsu Kishimoto is a Japanese immunologist known for research on IgM and cytokines, most famously, interleukin 6.

He did postdoctoral work under Kimishige Ishizaka, the discoverer of IgE at Johns Hopkins University.

He is listed by the Institute for Scientific Information ISI as a highly cited biologist and he is also in the top ten of h-index of living biologists.

                                     

1. Life

Tadamitsu Kishimoto, who was born in Osaka in 1939, was President of Osaka University from 1997 to 2003 and a Member, Council for Science and Technology Policy, Cabinet office from 2004 to 2006. He is now Professor, Graduate School of Frontier Biosciences, Osaka University. He was Dean, Professor and Chairman of Department of Medicine at Osaka University Medical School from which he graduated in 1964. He is currently Japans leading scientist in the field of life science, specifically in immunology and has made fundamental contributions to the understanding of cytokine functions through series of his studies on IL-6, its receptor system, and transcription factors. He has developed anti-IL6 receptor therapy for several immune disorders including Castlemans disease, rheumatoid arthritis and juvenile idiopathic arthritis.

He has received numerous awards, including the Imperial Prize of the Japan Academy in 1992, the Sandoz Prize for Immunology from the International Union of Immunological Society in 1992 and the Avery-Landsteiner Prize from the German Immunology Society in 1996. In 1998, he was awarded the Order of Culture from Emperor. He was awarded Robert Koch Gold Medal in 2003, Honorary Life Time Achievement Awards from International Cytokine Society in 2006 and the Crafoord Award from the Royal Swedish Academy of Sciences in 2009. He has been elected a Foreign Associate of the US National Academy of Sciences in 1991, a member of the Japan Academy in 1995 and a member of Deutsche Akademie der Naturforscher Leopoldina in 2005. He served as a president of the International Immunopharmacology Society, International Cytokine Society and the Japanese Immunology Society. He is an honorary member in American Association of Immunologists and American Society of Hematology.

                                     

2. IL-6

In the early 1970s, Kishimoto discovered the activity inducing antibody production in culture supernatants of T cells. Furthermore, he demonstrated that the activity for inducing IgG and IgE antibodies could be separated. Later, this finding led to the discovery of the dichotomy of helper T cells, Th1 and Th2. On the basis of these early studies, Kishimoto discovered and cloned interleukin-6 and its receptor and delineated the signaling pathway used by IL-6 and the set of related cytokines that utilize gp-130, which he also discovered. He identified the transcription factors NF-IL-6 and STAT3, both central to the action of IL-6. He further discovered a family of suppressors of cytokine signaling, the SOCS molecules, that are key regulators of cytokine function. He demonstrated the involvement of IL-6 in the pathogenesis of cardiac myxomas, multiple myeloma, Castleman’s disease, rheumatoid arthritis, Crohns disease and juvenile idiopathic arthritis JIA. He identified IL-6 as a hepatocyte stimulating factor which induces acute phase reactions. He prepared a monoclonal anti-IL-6 receptor antibody that was subsequently humanized and has been shown to be of great therapeutic value in a series of autoinflammatory diseases including Castlemans Disease, rheumatoid arthritis and juvenile idiopathic arthritis. His work has dominated the field of proinflammatory cytokines and has established paradigms for the study of all of cytokine biology, ranging from discovery of the cytokine and its receptor, through signaling and transcriptional mechanisms, to the utilization of such knowledge to develop highly effective therapeutics. A series of his IL-6 studies for 35 years since 1973 have been highly appreciated; He was ranked as the world’s 8th-most-cited researchers between 1983 and 2002 and he is in the top ten of h-index of living biologists.

                                     
  • Tetsuji Sugiyama, Kenji Barsumian, Edward L Suemura, Masaki Kishimoto Tadamitsu 2007 Structure and Function of Fcε Receptor II FcεRII CD23
  • Institutions University of Colorado Denver Johns Hopkins University La Jolla Institute for Allergy and Immunology Notable students Tadamitsu Kishimoto
  • 1983 John Kappler National Jewish Medical and Research Center 1989 Tadamitsu Kishimoto Osaka University 1991 Lewis Lanier University of California, San
  • understanding their role in the onset of inflammatory diseases Tadamitsu Kishimoto Japanese Toshio Hirano Japanese 2010 Geosciences Walter Munk American
  •  United States United States for writing the Unix operating system. Tadamitsu Kishimoto Toshio Hirano Japan Japan for the discovery of interleukin - 6. 2010
  • 2017 Medicine Biologic Therapeutics in Autoimmune Diseases Japan Tadamitsu Kishimoto Professor 2018 Medicine Immunotherapy for Cancer United States James
  • Haynes David Ho Ralph I. Horwitz David E. Housman Suzanne T. Ildstad Tadamitsu Kishimoto Richard M. Knapp Risa Lavizzo - Mourey Howard Leventhal Charles Marsden

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